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Peptide Vaccine Against ADAMTS-7 Ameliorates Atherosclerosis and Postinjury Neointima Hyperplasia by Zihan Ma; Chenfeng Mao; Xiao Chen; Shiyu Yang; Zhihua Qiu; Baoqi Yu; Yiting Jia; Chao Wu; Yiyi Wang; Yuhui Wang; Rui Gu; Fang Yu; Yanhui Yin; Xian Wang; Qingbo Xu; Chuanju Liu; Yuhua Liao; Jingang Zheng; Yi Fu; Wei Kong is a Medicine article available to read on EtoBox.
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## BACKGROUND: The metalloprotease ADAMTS-7 (a disintegrin and metalloproteinase with thrombospondin type 1 motif 7) is a novel locus associated with human coronary atherosclerosis. ADAMTS-7 deletion protects against atherosclerosis and vascular restenosis in rodents. ## METHODS: We designed 3 potential vaccines consisting of distinct B cell epitopic peptides derived from ADAMTS-7 and conjugated with the carrier protein KLH (keyhole limpet hemocyanin) as well as aluminum hydroxide as an adjuvant. Arterial ligation or wire injury was used to induce neointima in mice, whereas ApoE -/-and LDLR -/-(LDLR [low-density lipoprotein receptor]) mice fed a high-fat diet were applied to assess atherosclerosis. In addition, coronary stent implantation was performed on vaccine-immunized Bama miniature pigs, followed by optical coherence tomography to evaluate coronary intimal hyperplasia. ## RESULTS: A vaccine, ATS7vac, was screened out from 3 candidates to effectively inhibit intimal thickening in murine carotid artery ligation models after vaccination. As well, immunization with ATS7vac alleviated neointima formation in murine wire injury models and mitigated atherosclerotic lesions in both hy
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- Author
- Zihan Ma; Chenfeng Mao; Xiao Chen; Shiyu Yang; Zhihua Qiu; Baoqi Yu; Yiting Jia; Chao Wu; Yiyi Wang; Yuhui Wang; Rui Gu; Fang Yu; Yanhui Yin; Xian Wang; Qingbo Xu; Chuanju Liu; Yuhua Liao; Jingang Zheng; Yi Fu; Wei Kong
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)