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Can I read Multi-residue Method for the Determination of Thyreostats in Urine Samples Using Liquid Chromatography Coupled to Tandem Mass Spectrometry After Derivatisation with 3-Iodobenzylbromide on EtoBox?
Multi-residue Method for the Determination of Thyreostats in Urine Samples Using Liquid Chromatography Coupled to Tandem Mass Spectrometry After Derivatisation with 3-Iodobenzylbromide by Gaud Pinel; Emmanuelle Bichon; Karine Pouponneau; Daniel Maume; François André; Bruno Le Bizec is a Chemistry article available to read on EtoBox.
What is Multi-residue Method for the Determination of Thyreostats in Urine Samples Using Liquid Chromatography Coupled to Tandem Mass Spectrometry After Derivatisation with 3-Iodobenzylbromide about?
Thyreostats are banned compounds in Europe since 1981 (directive 81/602/EC) because of their carcinogenic and teratogenic properties. The control of their illegal use in breeding animals is amongst the most difficult because of their low molecular weight, high polarity and the existence of tautomeric forms. The analytical procedure described in this paper involves, after a derivatisation step with 3-iodobenzylbromide, the detection and identification at low level (g/L) by LC-ESI(-)-MS/MS of eight thyreostats in various biological matrices (urine, muscle, liver, thyroid, animal feed, faeces and hair). The urine method has been validated according to the EU criteria (2002/657/EC decision): CC ␣ and CC  were found in the range (0.1-5.2 g/L) and (2.6-23.2 g/L), respectively. The performances fulfil the requirements of the EU regarding the provisional minimum required performance limit (MRPL) fixed at 100 g/L in urine.
Who reads Multi-residue Method for the Determination of Thyreostats in Urine Samples Using Liquid Chromatography Coupled to Tandem Mass Spectrometry After Derivatisation with 3-Iodobenzylbromide?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Gaud Pinel; Emmanuelle Bichon; Karine Pouponneau; Daniel Maume; François André; Bruno Le Bizec
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-3778)
- Published
- 2005
- Language
- EN
- Field
- Chemistry (Physical Sciences)