Can I read Granulin-epithelin Precursor Is a Novel Prognostic Marker in Epithelial Ovarian Carcinoma on EtoBox?
Granulin-epithelin Precursor Is a Novel Prognostic Marker in Epithelial Ovarian Carcinoma by Ben Davidson; Emilyn Alejandro; Vivi Ann Flørenes; Jeanne-Mette Goderstad; Björn Risberg; Gunnar B. Kristensen; Claes G. Trope; Elise C. Kohn is a Medicine article available to read on EtoBox.
What is Granulin-epithelin Precursor Is a Novel Prognostic Marker in Epithelial Ovarian Carcinoma about?
## Abstract ## BACKGROUND The granulin‐epithelin precursor (GEP) was preferentially expressed in invasive ovarian tumor epithelium specimens compared with specimens of borderline ovarian tumors. The objective of the current study was to evaluate the anatomic site‐related and cellular expression of GEP and its association with clinicopathologic parameters and survival in patients with advanced‐stage ovarian carcinoma. ## METHODS Effusions (__n__ = 190), corresponding primary tumor specimens (__n__ = 64), and specimens of metastatic lesions (__n__ = 125) were analyzed using immunohistochemistry with a specific polyclonal antipeptide antibody. In addition, 36 effusions were analyzed using immunoblotting. ## RESULTS GEP was detected in tumor cells in 171 of 190 (90%) effusions and demonstrated both focal membrane and cytoplasmic localization. Mesothelial cells were often GEP positive (81%). GEP was found in carcinoma cells in 180 of 189 (95%) tumor biopsy specimens, with stromal and endothelial cell expression in 93 of 180 (52%) and 124 of 185 (67%) specimens, respectively. Lower GEP expression in stromal cells was observed in metastases sampled during or after chemotherapy (__P__ = 0.
Who reads Granulin-epithelin Precursor Is a Novel Prognostic Marker in Epithelial Ovarian Carcinoma?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Ben Davidson; Emilyn Alejandro; Vivi Ann Flørenes; Jeanne-Mette Goderstad; Björn Risberg; Gunnar B. Kristensen; Claes G. Trope; Elise C. Kohn
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 2004
- Language
- EN
- Field
- Medicine (Health Sciences)