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CRISPR Screening with Spatial Transcriptomics by cellina is a document available to read on EtoBox.

What is CRISPR Screening with Spatial Transcriptomics about?

The article introduces Perturb-FISH, a novel method that integrates high-throughput imaging spatial transcriptomics with in situ guide RNA detection to analyze molecular and functional states at the single-cell level. This technique allows for the recovery of genetic perturbation effects on the transcriptome, revealing specific genetic networks related to neighboring cells and their interactions. Perturb-FISH demonstrates its utility in studying genetic and molecular associations in various biological conte

Author

cellina

Language

EN