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Population Pharmacokinetics of Teicoplanin in Preterm and Term Neonates: Is It Time for a New Dosing Regimen? by Kontou, A. (author);Sarafidis, K. (author);Begou, O. (author);Gika, H. G. (author);Tsiligiannis, A. (author);Ogungbenro, K. (author);Dokoumetzidis, A. (author);Agakidou, E. (author);Roilides, E. (author) is a Medicine article available to read on EtoBox.

What is Population Pharmacokinetics of Teicoplanin in Preterm and Term Neonates: Is It Time for a New Dosing Regimen? about?

Our objective was to develop a population pharmacokinetic (PK) model in order to evaluate the currently recommended dosing regimen in term and preterm neonates. By using an optimal design approach, a prospective PK study was designed and implemented in 60 neonates with postmenstrual ages (PMA) of 26 to 43 weeks. A loading dose of 16 mg/kg was administered at day 1, followed by a maintenance dose of 8 mg/kg daily. Plasma concentrations were quantified by high-pressure liquid chromatography-mass spectrometry. Population PK (popPK) analysis was performed using NONMEM software. Monte-Carlo (MC) simulations were performed to evaluate currently recommended dosing based on a pharmacodynamic index of area under the concentration-time curve (AUC)/MIC ratio of ≥400. A two-compartment model with linear elimination best described the data by the following equations: clearance (CL) = 0.0227 × (weight [wt]/1,765) × (estimated creatinine clearance [eCRCL]/22), central compartment volume of distribution (V1) = 0.283 (wt/1,765), intercompartmental clearance () = 0.151 (wt/1,765), and peripheral compartment volume (V2) = 0.541 (wt/1,765). The interindividual variability estimates for CL, V1, and V2

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Author
Kontou, A. (author);Sarafidis, K. (author);Begou, O. (author);Gika, H. G. (author);Tsiligiannis, A. (author);Ogungbenro, K. (author);Dokoumetzidis, A. (author);Agakidou, E. (author);Roilides, E. (author)
Publisher
American Society for Microbiology
Published
2020
Language
EN
Field
Medicine (Health Sciences)

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