Can I read Change in Bronchial Responsiveness and Cough Reflex Sensitivity in Patients with Cough Variant Asthma: Effect of Inhaled Corticosteroids on EtoBox?

Change in Bronchial Responsiveness and Cough Reflex Sensitivity in Patients with Cough Variant Asthma: Effect of Inhaled Corticosteroids by Masaki Fujimura; Johsuke Hara; Shigeharu Myou is a Medicine article available to read on EtoBox.

What is Change in Bronchial Responsiveness and Cough Reflex Sensitivity in Patients with Cough Variant Asthma: Effect of Inhaled Corticosteroids about?

## Background Cough variant asthma (CVA) is a cause of chronic cough and a precursor of typical asthma. We retrospectively examined the longitudinal change in bronchial responsiveness and cough reflex sensitivity in CVA patients with respect to the effect of long-term inhaled corticosteroids (ICS). ## Methods Provocative concentration of methacholine causing a 20% fall in forced expiratory volume in one second (PC20-FEV1) and provocative concentration of capsaicin eliciting 5 or more coughs (C5) were measured before treatment and during a follow up period following relief of cough (median; 2.0 (range; 0.5 to 8.0) years after the initial visit) in a total of 20 patients with CVA (7 males and 13 females, mean ± SD age of 49.9 ± 12.9 years). ## Results Three of 8 patients not taking long-term ICS developed typical asthma compared to none of 12 patients taking ICS (p = 0.0171). PC20-FEV1 significantly (p < 0.0001) increased from 1.80 (GSEM, 1.35) to 10.7 (GSEM, 1.63) mg/ml in patients taking ICS but did not change in patients not taking ICS [2.10 (GSEM, 1.47) compared to 2.13 (GSEM, 1.52) mg/ml]. Cough threshold did not change in patients whether taking or not taking ICS. ## Conclusion

Who reads Change in Bronchial Responsiveness and Cough Reflex Sensitivity in Patients with Cough Variant Asthma: Effect of Inhaled Corticosteroids?

Author

Masaki Fujimura; Johsuke Hara; Shigeharu Myou

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: Biomed Central, 2005-2014.; Springer Science and Business Media LLC (ISSN 1745-9974)

Published

2005

Language

EN

ISBN

9781745997411

Field

Medicine (Health Sciences)