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The study investigates the autocrine effects of the astrocytic protein S100B on astrocytes, specifically its role in upregulating IL-6 and TNF-alpha expression via the receptor for advanced glycation end products (RAGE). S100B was shown to stimulate cytokine secretion in a concentration- and time-dependent manner, and this effect was blocked by RAGE-specific siRNA. The findings suggest that S100B may induce proinflammatory responses in astrocytes through RAGE, similar to its effects in neurons and microglia

Author

Patrícia Nardin

Language

EN