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The Impact of Geometric Uncertainty on Hypofractionated External Beam Radiation Therapy of Prostate Cancer by Tim Craig; Vitali Moiseenko; Jerry Battista; Jake Van Dyk is a Medicine article available to read on EtoBox.

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Purpose: Recent publications indicate ␣/␤ for prostate carcinoma could be lower than assumed. Therefore, hypofractionation might increase the therapeutic ratio. However, patient repositioning and organ motion may affect hypofractionated treatments more than conventional treatments. Our purpose is to evaluate the potential impact of geometric uncertainties on hypofractionated treatments. Methods and Materials: Tumor control probability (TCP) and normal tissue complication probability (NTCP) are calculated for simulated conventional and hypofractionated treatments, assuming ␣/␤ of 1.5 Gy for prostate and 3.0 Gy for rectum. A Monte Carlo simulation randomly samples systematic and random displacements and produces the cumulative dose distribution for the prostate and rectum. The limiting number of fractions and the impact of different ␣/␤ values are also explored. Results: A consistent but small reduction in TCP is seen with hypofractionation (generally <1%) as a result of geometric uncertainties. Escalated hypofractionation seems to allow large TCP gains (ϳ20%) without increasing NTCP. Treatments of five fractions seem to affect outcome minimally. The ␣/␤ value has a much greater impa

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Author

Tim Craig; Vitali Moiseenko; Jerry Battista; Jake Van Dyk

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2003

Language

EN

Field

Medicine (Health Sciences)