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Pharmaceutical Hot Melt Extrusion (HME) is a continuous production method for oral dosages that enhances the bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs) by dissolving them in molten polymer excipients. The process involves critical steps of melting, mixing, and API dissolution, which occur simultaneously to ensure effective incorporation of APIs into the polymer matrix. Current research focuses on optimizing these processes to improve drug formulation and stability, part

Author

Juan Felipe Valencia Vélez

Language

EN