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1) Rhesus macaques were vaccinated with recombinant SIV Gag-Pol particles, HIV-1 Tat protein, and trimeric HIV-C gp160 protein to induce both humoral and cellular immune responses. 2) After five low-dose challenges with the heterologous SHIV-1157ipEL-p virus, one third of vaccinated macaques remained virus-free compared to only 6% of control macaques. 3) Upon high-dose SHIV rechallenge, some vaccinated macaques remained aviremic while all control macaques became infected, and peak viremia levels correlat

Author

pondokbetung

Language

EN