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The study investigates polyethyleneimine (PEI)-modified calcium-pectinate beads for colon-specific drug delivery, using resveratrol as a model drug. The optimized beads demonstrated effective drug release in simulated colonic fluid while preventing release in upper gastrointestinal conditions, with in vivo studies showing delayed drug appearance in blood after oral administration. This formulation addresses challenges in delivering therapeutics for colonic diseases by enhancing stability and targeting drug

Author

surodasju03

Language

EN