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Background.\p=m-\To determine the incidence of agranulo- cytosis, a descriptive epidemiologic study was performed. Methods.\p=m-\With the use of computerized Medicaid bill- ing data from 1980 through 1985 from Minnesota, Michi- gan, and Florida, the ratio of persons hospitalized with a discharge diagnosis of neutropenia to persons with any claim for medical service was first used as an estimate of the incidence rate of the condition. Patients with cancer and patients receiving cytotoxic and immunosuppressive drugs were excluded. The information provided by a review of medical records for a subset of neutropenia cases was used to determine the proportion with neutropenia after exclud- ing cases with recurrent or chronic neutropenia, and to de- termine the proportion with agranulocytosis. Results.\p=m-\The incidence rates (95% confidence intervals) of agranulocytosis, excluding recurrent or chronic disease, were 2.3 (1.4 to 3.7), 7.7(6.6 to 8.9), and 15.4 (11.3 to 20.4) per million per year in each state, respectively. The overall incidence was 7.2 (6.3 to 8.1) per million per year. Conclusions.\p=m-\ Agranulocytosis is an extremely uncom- mon condition. The excess risk of agranulocy

Who reads Descriptive Epidemiology of Agranulocytosis?

Author

Brian L. Strom

Publisher

American Medical Association (AMA)

Published

1992

Language

EN

Field

Medicine (Health Sciences)