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Two‐step Test: the Combined Use of Fetal Fibronectin and Sonographic Examination of the Uterine Cervix for Prediction of Preterm Delivery in Symptomatic Patients by PIOTR HINCZ; JAN WILCZYNSKI; MAREK KOZARZEWSKI; KRZYSZTOF SZAFLIK is a Medicine article available to read on EtoBox.
What is Two‐step Test: the Combined Use of Fetal Fibronectin and Sonographic Examination of the Uterine Cervix for Prediction of Preterm Delivery in Symptomatic Patients about?
**Purpose.** Our purpose was to assess the possibility of combined use of fetal fibronectin testing and sonographic examination of the uterine cervix for prediction of preterm deliveries. **Methods.** We prospectively evaluated 82 patients with preterm labor. In each case fibronectin testing and sonographic examination of the cervix were performed. The primary outcome measure was preterm delivery within 28 days. **Results.** Seventeen point one percent of the examined women delivered within 28 days. Among the analyzed sonographic parameters of the cervix only the functional canal length was significantly correlated with delivery (21.6±7.0 mm __vs__. 30.1±6.5 mm, __p__<0.001). Positive fetal fibronectin was found in 71.4% of patients delivered within 28 days and in 7.4% delivered after 28 days (__p__ 31 mm as a negative one. The fibronectin testing should be performed only in patients with length 21–31 mm. Two step testing had overall sensitivity of 86%, specificity of 90%, positive predictive value of 63% and negative of 97% for predicting delivery within 28 days. **Conclusions.** The proposed combined use of the cervical sonography and fetal fibronectin testing is a practical diag
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- Author
- PIOTR HINCZ; JAN WILCZYNSKI; MAREK KOZARZEWSKI; KRZYSZTOF SZAFLIK
- Publisher
- Informa plc; Wiley (Blackwell Publishing); Wiley-Blackwell; Wiley (ISSN 0001-6349)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)