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Changing body temperature affects the T signal in the rat brain and reveals hypothalamic activity by G. Vanhoutte; M. Verhoye; A. Van der Linden is a Medicine article available to read on EtoBox.

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## Abstract This study was designed to determine brain activity in the hypothalamus—in particular the thermoregulatory function of the hypothalamic preoptic area (PO). We experimentally changed the body temperature in rats within the physiological range (37–39°C) and monitored changes in blood oxygenation level‐dependent (BOLD) MR signal. To explore PO activity we had to deal with general signal changes caused by temperature‐dependent alterations in the affinity of oxygen for hemoglobin, which contributes to BOLD contrast because it is partly sensitive to the amount of paramagnetic deoxyhemoglobin in the voxel. To reduce these overall temperature‐induced effects, we corrected the BOLD data using brain‐specific correction algorithms. The results showed activity of the PO during body warming from 38°C to 39°C, supported by an increased BOLD signal after correction. This is the first fMRI study on the autonomous nervous system in which hypothalamic activity elicited by changes in the internal environment (body temperature) was monitored. In this study we also demonstrate 1) that any fMRI study of anesthetized small animals should guard against background BOLD signal drift, since anima

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Author

G. Vanhoutte; M. Verhoye; A. Van der Linden

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)

Published

2006

Language

EN

Field

Medicine (Health Sciences)