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The PRECISION trial evaluated the efficacy of aprocitentan, a dual endothelin antagonist, in lowering blood pressure in patients with resistant hypertension. The study found that aprocitentan significantly reduced office systolic blood pressure compared to placebo, with sustained effects observed at 40 weeks. Aprocitentan was well tolerated, although mild-to-moderate edema was noted as a common adverse event.

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nkpk.pradeep

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EN