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Gene–lifecourse interaction for alcohol consumption in adolescence and young adulthood: Five monoamine genes by Guang Guo; Kirk Wilhelmsen; Nathan Hamilton is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Association analysis has suggested that common sequence variants of genes that affect monoamine function can affect substance use and abuse. Demonstration of these associations has been inconsistent because of limited sample sizes and phenotype definition. Drawing on the life course perspective, we predicted a stronger association between the polymorphisms in __5HTT, DAT1, DRD4, DRD2__, and __MAOA__ and alcohol consumption in young adulthood than adolescence. This analysis tested for the gene–lifecourse interaction for the frequency of alcohol consumption in a nationally representative non‐alcohol‐dependent sample of 2,466 individuals that were visited during adolescence and young adulthood for four times between 1994 and 2002. All five genes are significantly associated with the frequency of alcohol consumption, with the genotype effects ranging 7%–20% of the mean score of alcohol consumption and their __P__ values being 0.014, 0.0003, 0.003, 0.007, 0.005, and 0.003, respectively. The association is only observed in the life stage of young adulthood and not in adolescence. This analysis has demonstrated the potential usefulness of the life course perspective in genetic

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Author

Guang Guo; Kirk Wilhelmsen; Nathan Hamilton

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 1552-4841)

Published

2007

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)