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Effect of eplerenone on clinical stability of Japanese patients with acute heart failure by Masatake Kobayashi; João Pedro Ferreira; Yuya Matsue; Taishiro Chikamori; Shin Ito; Masanori Asakura; Akira Yamashina; Masafumi Kitakaze is a Medicine article available to read on EtoBox.

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Background: In the EARLIER (Efficacy and Safety of Early Initiation of Eplerenone Treatment in Patients with Acute Heart Failure) trial, eplerenone did not reduce heart failure (HF) hospitalizations or all-cause mortality in 300 patients admitted for acute HF (AHF). However, the trial might have been underpowered for these endpoints, and a comprehensive overview of the effect of eplerenone on diuretic doses and patients' clinical stability is warranted. Methods: The EARLIER trial included Japanese patients hospitalized for AHF randomly assigned to eplerenone or placebo over 6 months. Cox proportional hazards and mixed-effects models were used for analyses. Results: Three hundred patients were included (mean age, 67 ± 13 years; 73% males). The median furosemide equivalent dose was 40 (20-62) mg at randomization. Patients with higher furosemide-equivalent doses had more severe signs and symptoms of congestion and a higher risk of all-cause mortality or HF hospitalization during 6-month follow-up (adjusted-hazard ratio per 10 mg/day increase = 1.25, 95% confidence interval: 1.05-1.49). Eplerenone significantly decreased furosemide-equivalent diuretic doses and b-type natriuretic level

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Author

Masatake Kobayashi; João Pedro Ferreira; Yuya Matsue; Taishiro Chikamori; Shin Ito; Masanori Asakura; Akira Yamashina; Masafumi Kitakaze

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)