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Hyperhomocysteinaemia is not associated with isolated crural arterial occlusive disease: The Hoorn Study by E. K. Hoogeveen; P. J. Kostense; C. Jakobs; J. A. Rauwerda; J. M. Dekker; G. Nijpels; L. M. Bouter; R. J. Heine; C. D. A. Stehouwer is a Medicine article available to read on EtoBox.

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**Abstract.** Hoogeveen EK, Kostense PJ, Jakobs C, Rauwerda JA, Dekker JM, Nijpels G, Bouter LM, Heine RJ, Stehouwer CDA (University Hospital Vrije Universiteit, Amsterdam). Hyperhomocysteinaemia is not associated with isolated crural arterial occlusive disease: the Hoorn Study. __J Intern Med__ 2000; **247**: 442–448. **Objectives.** Hyperhomocysteinaemia is an independent risk factor for peripheral arterial disease (PAD). The localization of peripheral arterial disease is clinically relevant, because proximal (aortoiliac and femoropopliteal) disease is associated with a particularly poor overall prognosis, whereas isolated distal (i.e. crural) disease is associated with a better overall prognosis. The aim of the study was to investigate whether the strength of the association between hyperhomocysteinaemia and peripheral arterial disease differs according to the localization of the anatomical obstruction. **Design.** Fasting serum total homocysteine (tHcy) was measured in an age‐, sex‐ and glucose‐tolerance stratified random sample (__n__ = 631) of a 50‐ to 75‐year‐old general Caucasian population. History of a peripheral arterial reconstruction was recorded. Aortoiliac, femoropop

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Author
E. K. Hoogeveen; P. J. Kostense; C. Jakobs; J. A. Rauwerda; J. M. Dekker; G. Nijpels; L. M. Bouter; R. J. Heine; C. D. A. Stehouwer
Publisher
John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0954-6820)
Published
2000
Language
EN
Field
Medicine (Health Sciences)

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Browse all works by E. K. Hoogeveen; P. J. Kostense; C. Jakobs; J. A. Rauwerda; J. M. Dekker; G. Nijpels; L. M. Bouter; R. J. Heine; C. D. A. Stehouwer