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Gastrointestinal Involvement of Autism Spectrum Disorder: Focus on Gut Microbiota by Carlo Romano Settanni; Stefano Bibbò; Gianluca Ianiro; Emanuele Rinninella; Marco Cintoni; Maria Cristina Mele; Giovanni Cammarota; Antonio Gasbarrini is a Medicine article available to read on EtoBox.

What is Gastrointestinal Involvement of Autism Spectrum Disorder: Focus on Gut Microbiota about?

## Introduction: Autism spectrum disorder (asd) is a neurodevelopmental disorder typical of early age, characterized by impaired communication, social interaction, and repetitive behaviors. asd patients frequently suffer from gastrointestinal (gi) symptoms. neuro-psychological functions, intestinal homeostasis, and functional gi disturbances are modulated by the gut microbiota through the so-called 'microbiota-gut-brain axis'. ## Areas covered: Literature regarding gi symptoms among the asd community as well as the involvement and modulation of the gut microbiota in gi disturbances of asd patients was searched. constipation, diarrhea, reflux, abdominal bloating, pain, and discomfort are reported with variable prevalence. asd is characterized by a reduction of /, of the abundance of and other imbalances. asd patients with gi symptoms present microbial changes with plausible relation with deficiency of digestive enzymes, carbohydrate malabsorption, selective eating, bacterial toxins, serotonin metabolism, and inflammation. the strategies to mitigate the gi distress through the gut microbiota modulation comprise antimicrobials, probiotics, prebiotics, fecal microbiota transplantation,

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Author

Carlo Romano Settanni; Stefano Bibbò; Gianluca Ianiro; Emanuele Rinninella; Marco Cintoni; Maria Cristina Mele; Giovanni Cammarota; Antonio Gasbarrini

Publisher

Informa UK Limited

Published

2020

Language

EN

Field

Medicine (Health Sciences)