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This review discusses the role of protamines in sperm DNA packaging and their complex functions revealed through mouse models. It highlights that both protamines, PRM1 and PRM2, are essential for sperm functionality, with distinct roles beyond DNA compaction, particularly in sperm motility and chromatin reorganization. The review also emphasizes the significance of the protamine ratio across species and its implications for male fertility.

Author

WOW

Language

EN