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Increased Serum 12-Hydroxyeicosatetraenoic Acid Levels Are Correlated with an Increased Risk of Diabetic Retinopathy in Both Children and Adults with Diabetes by Shuli Chen; Yu Qian; Qiurong Lin; Zhangling Chen; Zhaoyu Xiang; Lipu Cui; Jiaqi Sun; Xinran Qin; Yi Xu; Lina Lu; Haidong Zou is a Medicine article available to read on EtoBox.
What is Increased Serum 12-Hydroxyeicosatetraenoic Acid Levels Are Correlated with an Increased Risk of Diabetic Retinopathy in Both Children and Adults with Diabetes about?
## Purpose: To investigate the relationship between serum 12-hydroxyeicosatetraenoic acid (12-hete) and diabetic retinopathy (dr) in children with type 1 diabetes mellitus (t1dm) and adults with type 2 diabetes mellitus (t2dm). ## Methods: Children from the shanghai children and adolescent diabetes eye (scade) study and adults from the shanghai cohort study of diabetic eye disease (scode) were examined in 2021. serum 12-hete levels were detected and compared. multivariate logistic regression was used to analyze the relationship between 12-hete and the rate of dr in diabetic patients. ## Results: The child study included 4 patients with new-onset dr and 24 patients with t1dm without dr. in children with t1dm, the 12-hete level was significantly higher in those with dr (p = 0.003). the adult study had two sets, for testing and verification. the test set included 28 patients with new-onset dr and 24 t2dm patients with a course of ≥ 20 years who had never developed dr. the verification set included 41 patients with dr, 50 patients without dr and 50 healthy controls. in the adult test set, the 12-hete level was significantly higher in patients with dr than in those with t2dm without dr
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- Author
- Shuli Chen; Yu Qian; Qiurong Lin; Zhangling Chen; Zhaoyu Xiang; Lipu Cui; Jiaqi Sun; Xinran Qin; Yi Xu; Lina Lu; Haidong Zou
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)