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Can I read HDL (High-Density Lipoprotein) and ApoA-1 (Apolipoprotein A-1) Potentially Modulate Pancreatic α-Cell Glucagon Secretion on EtoBox?
HDL (High-Density Lipoprotein) and ApoA-1 (Apolipoprotein A-1) Potentially Modulate Pancreatic α-Cell Glucagon Secretion by Mancuso, Elettra; Mannino, Gaia Chiara; Fuoco, Anastasia; Leo, Antonio; Citraro, Rita; Averta, Carolina; Spiga, Rosangela; Russo, Emilio; De Sarro, Giovambattista; Andreozzi, Francesco; Sesti, Giorgio is a Medicine article available to read on EtoBox.
What is HDL (High-Density Lipoprotein) and ApoA-1 (Apolipoprotein A-1) Potentially Modulate Pancreatic α-Cell Glucagon Secretion about?
## Objective: Subjects with low levels of HDL (high-density lipoprotein) and ApoA-1 (apolipoprotein A-1) have increased risk to develop type 2 diabetes. HDL levels are an independent predictor of β-cell function and positively modulate it. Type 2 diabetes is characterized by defects in both β and α-cell function, but the effect of HDL and ApoA1 on α-cell function is unknown. ## Approach and Results: We observed a significant negative correlation ( r =−0.422, P <0.0001) between HDL levels and fasting glucagon in a cohort of 132 Italian subjects. In a multivariable regression analysis including potential confounders such as age, sex, BMI, triglycerides, total cholesterol, fasting and 2-hour postload glucose, and fasting insulin, the association between HDL and fasting glucagon remained statistically significant (β=−0.318, P =0.006). CD1 mice treated with HDL or ApoA-1 for 3 consecutive days showed a 32% ( P <0.001) and 23% ( P <0.05) reduction, respectively, in glucagon levels following insulin-induced hypoglycemia, compared with controls. Treatment of pancreatic αTC1 clone 6 cells with HDL or ApoA-1 for 24 hours resulted in a significant reduction of glucagon expression ( P <0.04) a
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- Author
- Mancuso, Elettra; Mannino, Gaia Chiara; Fuoco, Anastasia; Leo, Antonio; Citraro, Rita; Averta, Carolina; Spiga, Rosangela; Russo, Emilio; De Sarro, Giovambattista; Andreozzi, Francesco; Sesti, Giorgio
- Publisher
- Lippincott Williams and Wilkins; Ovid Technologies Wolters Kluwer -American Heart Association; Lippincott Williams & Wilkins Ltd.; Ovid Technologies (Wolters Kluwer Health) (ISSN 1079-5642)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)