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Amphotericin B deoxycholate versus liposomal amphotericin B: effects on kidney function by Juan Pablo Botero Aguirre; Alejandra Maria Restrepo Hamid is a Medicine article available to read on EtoBox.
What is Amphotericin B deoxycholate versus liposomal amphotericin B: effects on kidney function about?
## Background: The incidence of invasive fungal infections has increased globally as a result of several factors. conventional amphotericin b (sodium deoxycholate) has been used as standard therapy for the treatment of invasive fungal infections; however, it is associated with adverse drug reactions, including acute kidney injury (aki). new formulations of amphotericin b have aimed to improve the safety profile of the conventional formulation. ## Objectives: This review aimed to assess the effects of amphotericin b deoxycholate versus liposomal amphotericin b on kidney function. ## Search methods: We searched cochrane kidney and transplant's specialised register to 10 march 2015 through contact with the trials' search co-ordinator using search terms relevant to this review. ## Selection criteria: We included randomised controlled trials (rcts) that compared amphotericin b sodium deoxycholate with liposomal amphotericin b. ## Data collection and analysis: Two authors independently assessed studies for eligibility and conducted risk of bias evaluation. ## Main results: We included 12 studies (2298 participants) in this review. of these, 10 were meta-analysed (2172 participants). lipo
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- Author
- Juan Pablo Botero Aguirre; Alejandra Maria Restrepo Hamid
- Publisher
- Wiley
- Published
- 2015
- Language
- EN
- Field
- Medicine (Health Sciences)