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Rapid induction and Ca^2+^ influx‐mediated suppression of vitamin D3 up‐regulated protein 1 (VDUP1) mRNA in cerebellar granule neurons undergoing apoptosis by Tatsuya Saitoh; Shuuitsu Tanaka; Tatsuro Koike is a Neuroscience article available to read on EtoBox.
What is Rapid induction and Ca^2+^ influx‐mediated suppression of vitamin D3 up‐regulated protein 1 (VDUP1) mRNA in cerebellar granule neurons undergoing apoptosis about?
Cerebellar granule neurons (CGNs) grown under depolarizing conditions with high K^+^ (HK; 30 mm) undergo apoptosis following replacement of HK by physiological K^+^ (5.4 mm). Differential display analysis identified eight genes up‐regulated in this paradigm of apoptosis. Vitamin D3 up‐regulated protein 1 (__VDUP1__) mRNA was markedly up‐regulated as early as 2 h following HK withdrawal. __VDUP1__ mRNA was up‐regulated in other paradigms of neuronal apoptosis as well both __in vitro__ and __in vivo__. HK effectively suppressed the up‐regulation of __VDUP1__ mRNA in CGNs undergoing apoptosis via Ca^2+^ influx through voltage‐dependent L‐type Ca^2+^ channels, which did not require __de novo__ protein synthesis. The up‐regulation occurred in parallel with that of the c‐__jun__ transcript and c‐jun protein phosphorylation. Moreover, SB203580, p38 mitogen‐activated protein kinase inhibitor, suppressed up‐regulation of both c‐__jun__ and __VDUP1__ mRNAs, and c‐jun phosphorylation in CGNs undergoing apoptosis. IGF‐1, one of the neuroprotective agents for CGNs, also inhibited __VDUP1__ mRNA up‐regulation through a phosphoinositide 3 kinase‐dependent pathway. These results suggest that the _
Who reads Rapid induction and Ca^2+^ influx‐mediated suppression of vitamin D3 up‐regulated protein 1 (VDUP1) mRNA in cerebellar granule neurons undergoing apoptosis?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Tatsuya Saitoh; Shuuitsu Tanaka; Tatsuro Koike
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3042)
- Published
- 2001
- Language
- EN
- Field
- Neuroscience (Life Sciences)