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Unearths IFNB1 immune infiltrates in SOP-related ossification of ligamentum flavum pathogenesis by You Zhang; Hongwei Huang; Honglin Chen; Peng Zhang; Yu Liu; Yanchi Gan; Xianwei Yan; Bin Xie; Hao Liu; Bowen He; Jingjing Tang; Gengyang Shen; Xiaobing Jiang; Hui Ren is a Medicine article available to read on EtoBox.

What is Unearths IFNB1 immune infiltrates in SOP-related ossification of ligamentum flavum pathogenesis about?

## Background Ossification of ligamentum flavum (OLF) is a hidden, indolent disease condition with variable unexplained etiology and pathology. Growing evidences show a correlation between senile osteoporosis (SOP) and OLF, but the fundamental relationship between SOP and OLF remains unclear. Therefore, the purpose of this work is to investigate unique SOP-related genes and their potential functions in OLF. ## Methods Gene Expression Omnibus (GEO) database was utilized to gather the mRNA expression data (GSE106253) and then analyzed by R software. A variety of methods, including ssGSEA, machine learning (LASSO and SVM-RFE), GO and KEGG enrichment, PPI network, transcription factor enrichment analysis (TFEA), GSEA and xCells were employed to verified the critical genes and signaling pathways. Furthermore, ligamentum flavum cells were cultured and used in vitro to identify the expression of the core genes. ## Results The preliminary identification of 236 SODEGs revealed their involvement in BP pathways associated with ossification, inflammation, and immune response, including the TNF signaling pathway, PI3K/AKT signaling pathway and osteoclast differentiation. Four down-regulated gen

Who reads Unearths IFNB1 immune infiltrates in SOP-related ossification of ligamentum flavum pathogenesis?

Author

You Zhang; Hongwei Huang; Honglin Chen; Peng Zhang; Yu Liu; Yanchi Gan; Xianwei Yan; Bin Xie; Hao Liu; Bowen He; Jingjing Tang; Gengyang Shen; Xiaobing Jiang; Hui Ren

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Physical Sciences)