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In vitro susceptibility to quinine and microsatellite variations of the Plasmodium falciparum Na^+^/H^+^ exchanger ( Pfnhe-1) gene: the absence of association in clinical isolates from the Republic of Congo by Sébastien Briolant; Stéphane Pelleau; Hervé Bogreau; Philippe Hovette; Agnès Zettor; Jacky Castello; Eric Baret; Rémy Amalvict; Christophe Rogier; Bruno Pradines is a Medicine article available to read on EtoBox.

What is In vitro susceptibility to quinine and microsatellite variations of the Plasmodium falciparum Na^+^/H^+^ exchanger ( Pfnhe-1) gene: the absence of association in clinical isolates from the Republic of Congo about?

## Background Quinine is still recommended as an effective therapy for severe cases of __Plasmodium falciparum__ malaria, but the parasite has developed resistance to the drug in some cases. Investigations into the genetic basis for quinine resistance (QNR) suggest that QNR is complex and involves several genes, with either an additive or a pairwise effect. The results obtained when assessing one of these genes, the plasmodial Na^+^/H^+^ exchanger, __Pfnhe-1__, were found to depend upon the geographic origin of the parasite strain. Most of the associations identified have been made in Asian strains; in contrast, in African strains, the influence of __Pfnhe__ on QNR is not apparent. However, a recent study carried out in Kenya did show a significant association between a __Pfnhe__ polymorphism and QNR. As genetic differences may exist across the African continent, more field data are needed to determine if this association exists in other African regions. In the present study, association between __Pfnhe__ and QNR is investigated in a series of isolates from central Africa. ## Methods The sequence analysis of the polymorphisms at the __Pfnhe-1__ ms4760 microsatellite and the evaluat

Who reads In vitro susceptibility to quinine and microsatellite variations of the Plasmodium falciparum Na^+^/H^+^ exchanger ( Pfnhe-1) gene: the absence of association in clinical isolates from the Republic of Congo?

Author

Sébastien Briolant; Stéphane Pelleau; Hervé Bogreau; Philippe Hovette; Agnès Zettor; Jacky Castello; Eric Baret; Rémy Amalvict; Christophe Rogier; Bruno Pradines

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2002-; Springer Science and Business Media LLC; Research Square (ISSN 1475-2875)

Published

2011

Language

EN

Field

Medicine (Health Sciences)