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High potent and selective arylpiperazine derivatives as ligands for the 5-HT 1A receptor by Maria Modica; Maria Santagati; Andrea Santagati; Filippo Russo; Alfredo Cagnotto; Mara Goegan; Tiziana Mennini is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is High potent and selective arylpiperazine derivatives as ligands for the 5-HT 1A receptor about?
AbstractÐThis paper reports the synthesis and anities on the 5-HT 1A versus the a 1 A receptors of new arylpiperazinylalkylthiothienopyrimidine and thiadiazole derivatives 16±24. Arylpiperazines 16±23 show anities values in the nanomolar range for the 5-HT 1A receptor. The compound 16 is highly potent (K i 0.26 nM, selectivity 28), the derivatives 20 and 21 are less potent, but highly selective (K i 9.40 and 5.06 nM, selectivity 207 and 73, respectively).
Who reads High potent and selective arylpiperazine derivatives as ligands for the 5-HT 1A receptor?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Maria Modica; Maria Santagati; Andrea Santagati; Filippo Russo; Alfredo Cagnotto; Mara Goegan; Tiziana Mennini
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2000
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)