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Evolution of Airway Hyperresponsiveness in Infants with Severe Congenital Diaphragmatic Hernia by Steven R. Boas; Geoffrey Kurland; Peter G. Greally; Etsuro K. Motoyama is a Medicine article available to read on EtoBox.

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Infants born with severe congenital diaphragmatic hernia (DH) characteristically have pulmonary hypoplasia. Airway hyperresponsiveness during the first 4 weeks of life can be demonstrated in most of these neonates. Early postnatal pulmonary development in infants with severe DH has not been well characterized. We examined lung growth in patients with congenital DH by using the forced deflation method to study pulmonary function in 18 infants on mechanical ventilation who survived neonatal repair of their congenital DH. Thirteen infants without primary pulmonary pathology who required general anesthesia for other surgery served as controls. Infants were further divided according to age at the time of testing into early (age 5 7 days at time of testing) and late (age 2 29 days) groups, yielding four groups of subjects: early diaphragmatic hernia (EDH): n = 9; mean age, 4.2 days; range, 1-7 days; early controls (EC): n = 8; mean age, 3.1 days; range, 1-6 days; late diaphragmatic hernia (LDH): n = 11; mean age, 57.7 days, range, 28-120 days; and late controls (LC); n = 5; mean age, 52.2 days; range 32-90 days. All infants were studied once, with the exception of two infants with DH who

Who reads Evolution of Airway Hyperresponsiveness in Infants with Severe Congenital Diaphragmatic Hernia?

Author

Steven R. Boas; Geoffrey Kurland; Peter G. Greally; Etsuro K. Motoyama

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 8755-6863)

Published

1996

Language

EN

Field

Medicine (Health Sciences)