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Effects of lead on rat kidney and liver: GST expression and oxidative stress by Daniel A Daggett; Terry D Oberley; Shelli A Nelson; Lynda S Wright; Steven E Kornguth; Frank L Siegel is a Environmental Science article available to read on EtoBox.

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The effect of acute exposure to lead acetate on the expression of glutathione S-transferase (GST) subunits and the levels of reduced and oxidized glutathione (GSH) and malondialdehyde (MDA) in rat kidney and liver was determined. The purpose of this study was to determine if GSH depletion and/or oxidative stress were responsible for changes in the expression of some or all GSTs that followed lead exposure. In kidney, all GST subunits increased following injection of lead. The level of kidney GSH was not changed at either 0.5 or 1 h after lead exposure, but increased 3, 6, 12 and 24 h after a single injection of lead. MDA levels (a marker of lipid peroxidation) did not change in kidney following lead injection. Immunohistochemical markers of oxidative stress and nitric oxide production were also unchanged by lead administration. Therefore. we conclude that the increases in GST levels in kidney following lead exposure were not dependent on oxidative stress. In liver, lead injection caused GSH depletion (61% of control 12 h after lead treatment) and increased MDA production (2.5-fold increase 6 h after lead exposure), while GSTA1, GSTA2, GSTM1 and GSTM2 did not increase. Analysis of t

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Author

Daniel A Daggett; Terry D Oberley; Shelli A Nelson; Lynda S Wright; Steven E Kornguth; Frank L Siegel

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0300-483X)

Published

1998

Language

EN

Field

Environmental Science (Life Sciences)