Can I read Cross-reactivity Among Drugs: Clinical Problems on EtoBox?

Cross-reactivity Among Drugs: Clinical Problems by Antonino Romano; Rosa-Maria Guéant-Rodriguez; Marinella Viola; Francesco Gaeta; Cristiano Caruso; Jean-Louis Guéant is a Environmental Science article available to read on EtoBox.

What is Cross-reactivity Among Drugs: Clinical Problems about?

Cross-reactivity among drugs is either mediated by immunologic mechanisms or not. The former kind is usually explained by the presence of common antigenic determinants in the cross-reacting drugs. In the case of compounds provoking non-allergic hypersensitivity reactions, cross-reactivity is explained by a common pharmacological characteristic, such as the inhibitory effect of non-steroidal anti-inflammatory drugs on cyclooxygenase-1 and the capability of muscle relaxants or contrast media to release histamine through a non-immunologic mechanism. The main clinical problem deriving from cross-reactivity among drugs is the compelling need to choose a potentially crossreactive compound and, therefore, to assess cross-reactivity by diagnostic tests. In choosing alternative compounds, skin testing has been used in evaluating IgE-mediated cross-reactivity between penicillins and cephalosporins, as well as among muscle relaxants. In assessing T cell-mediated cross-reactivity among contrast media, corticosteroids, anticonvulsants and heparins, delayedreading intradermal tests and patch tests, together with lymphocyte transformation tests, can be performed. Because of the limited sensitivit

Who reads Cross-reactivity Among Drugs: Clinical Problems?

Author

Antonino Romano; Rosa-Maria Guéant-Rodriguez; Marinella Viola; Francesco Gaeta; Cristiano Caruso; Jean-Louis Guéant

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0300-483X)

Published

2005

Language

EN

Field

Environmental Science (Life Sciences)