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Can I read Lipid Raft Proteome of the Human Neutrophil Azurophil Granule on EtoBox?
Lipid Raft Proteome of the Human Neutrophil Azurophil Granule by Elisabeth Feuk‐Lagerstedt; Charlotta Movitz; Sara Pellmé; Claes Dahlgren; Anna Karlsson is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Lipid Raft Proteome of the Human Neutrophil Azurophil Granule about?
## Abstract Detergent‐resistant membrane domains (DRMs) are present in the membranes of azurophil granules in human neutrophils (Feuk‐Lagerstedt et al., __J. Leukoc. Biol.__ 2002, __72__, 970). Using a proteomic approach, we have now identified 106 proteins in a DRM preparation from these granule membranes. Among these proteins were the lipid raft structural proteins flotillin‐1 and ‐2, cytoskeletal proteins such as actin, vimentin and tubulin, and membrane fusion promoting proteins like annexins and dysferlin. Our results suggest that the azurophil granule membrane, in similarity to the plasma membrane, is an elaborate structure that takes part in intracellular signaling and functions other than the mere delivery of bactericidal effector molecules to the phagosome.
Who reads Lipid Raft Proteome of the Human Neutrophil Azurophil Granule?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Elisabeth Feuk‐Lagerstedt; Charlotta Movitz; Sara Pellmé; Claes Dahlgren; Anna Karlsson
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley; Research Square (ISSN 1615-9853)
- Published
- 2007
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)