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Benzydamine HCl for prophylaxis of radiation-induced oral mucositis : Results from a multicenter, randomized, double-blind, placebo-controlled clinical trial by Joel B. Epstein; Sol Silverman Jr.; Dario A. Paggiarino; Steve Crockett; Mark M. Schubert; Neil N. Senzer; Peter B. Lockhart; Michael J. Gallagher; Douglas E. Peterson; Francis G. Leveque is a Medicine article available to read on EtoBox.
What is Benzydamine HCl for prophylaxis of radiation-induced oral mucositis : Results from a multicenter, randomized, double-blind, placebo-controlled clinical trial about?
## BACKGROUND. Benzydamine was evaluated in patients with head and neck carcinoma for treatment of radiation-induced oral mucositis, a frequent complication of radiation therapy (RT) for which there is no predictable therapy or preventive treatment currently available. ## METHODS. The safety and efficacy of 0.15% benzydamine oral rinse in preventing or decreasing erythema, ulceration, and pain associated with oral mucositis during RT were evaluated in a randomized, placebo-controlled trial conducted in patients with head and neck carcinoma. Subjects were to rinse with 15 mL for 2 minutes, 4 -8 times daily before and during RT, and for 2 weeks after completion of RT; study evaluations were conducted before RT and routinely thereafter up to 3 weeks after RT. ## RESULTS. During conventional RT, regimens up to cumulative doses of 5000 centigrays (cGy) benzydamine (n ϭ 69) significantly (P ϭ 0.006) reduced erythema and ulceration by approximately 30% compared with the placebo (n ϭ 76); greater than 33% of benzydamine subjects remained ulcer free compared with 18% of placebo subjects (P ϭ 0.037), and benzydamine significantly delayed the use of systemic analgesics compared with placebo (
Who reads Benzydamine HCl for prophylaxis of radiation-induced oral mucositis : Results from a multicenter, randomized, double-blind, placebo-controlled clinical trial?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Joel B. Epstein; Sol Silverman Jr.; Dario A. Paggiarino; Steve Crockett; Mark M. Schubert; Neil N. Senzer; Peter B. Lockhart; Michael J. Gallagher; Douglas E. Peterson; Francis G. Leveque
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)