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This Comparative Effectiveness Review evaluates the effectiveness and harms of opioid therapy for chronic noncancer pain, revealing that opioids provide only small improvements in pain and function compared to placebo, with significant risks of adverse effects. The review indicates no substantial differences between opioids and nonopioid medications in outcomes and highlights the need for further research on long-term effects and risk mitigation strategies. Additionally, the report underscores the dose-depe

Author

Coy Fernández Vivian Lizeth

Language

EN