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Increased dopamine D2^High^ receptors in amphetamine‐sensitized rats, measured by the agonist [^3^H](+)PHNO by Philip Seeman; Patrick N. Mccormick; Shitij Kapur is a Neuroscience article available to read on EtoBox.

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## Abstract Repeated injections of amphetamine causes animals to become sensitized and supersensitive to DA. Previous work showed that the striata from such sensitized rats revealed a 3.5‐fold increase in the density of D2^High^ DA receptors, as measured by the guanine‐nucleotide‐sensitive component of [^3^H]raclopride binding. The present study was done to confirm these earlier findings by different methods and different ligands. The striata from amphetamine‐sensitized rats showed an increase of 2.2‐fold in the density of guanine‐nucleotide‐sensitive D2 receptors labeled by saturation experiments with [^3^H](+)PHNO. The proportion of D2^High^ receptors was also found to increase 2.5‐fold using the method of competition between DA and [^3^H]domperidone. The overall 2.2–3.5‐fold increase of DA D2^High^ receptors may explain why amphetamine‐sensitized animals are much more sensitive to DA agonists, even though the total density of D2 receptors may apparently be unchanged or even decreased. Synapse 61:263–267, 2007. © 2007 Wiley‐Liss, Inc.

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Author

Philip Seeman; Patrick N. Mccormick; Shitij Kapur

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-4476)

Published

2007

Language

EN

Field

Neuroscience (Life Sciences)