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Digital UV/VIS imaging: a rapid PAT tool for crushing strength, drug content and particle size distribution determination in tablets by Lilla Alexandra Mészáros; Dorián László Galata; Lajos Madarász; Ákos Köte; Kristóf Csorba; Ádám Zoltán Dávid; András Domokos; Edina Szabó; Brigitta Nagy; György Marosi; Attila Farkas; Zsombor Kristóf Nagy is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.
What is Digital UV/VIS imaging: a rapid PAT tool for crushing strength, drug content and particle size distribution determination in tablets about?
The Process Analytical Technology (PAT) and the Quality-by-Design (QbD) approaches can efficiently facilitate the shift to the desired continuous manufacturing and real time release testing (RTRT). By this, it is vital to develop new, in-line analytical methods which fulfil the pharmaceutical requirements. The fast-developing digital imaging-based machine vision systems can provide revolutionary solutions not just in the automotive industry but in the pharmaceutical technology, as well. This study aimed to explore the capabilities of UV/VIS-based machine vision in tablet inspection as a PAT tool for the determination of compression force and crushing strength, drug content and drug distribution in tablets using meloxicam a yellow model drug. In the case of determining the compression force and crushing strength, the application of multivariate wavelet texture analysis (MWTA) based models provided relatively low prediction errors. To predict the drug content of meloxicam tablets CIELAB or RGB colorspace based algorithms were successfully developed and validated. UV/VIS imaging was also used to map the particle size distribution and spatial distribution of meloxicam, the results were
Who reads Digital UV/VIS imaging: a rapid PAT tool for crushing strength, drug content and particle size distribution determination in tablets?
It is typically read by researchers, students, and practitioners in Pharmacology, Toxicology and Pharmaceutics.
- Author
- Lilla Alexandra Mészáros; Dorián László Galata; Lajos Madarász; Ákos Köte; Kristóf Csorba; Ádám Zoltán Dávid; András Domokos; Edina Szabó; Brigitta Nagy; György Marosi; Attila Farkas; Zsombor Kristóf Nagy
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)
- Published
- 2020
- Language
- EN
- Field
- Pharmacology, Toxicology and Pharmaceutics (Life Sciences)