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What is 2023 Chen about?
The study presents a tetravalent nanoparticle vaccine designed to elicit a balanced and potent immune response against dengue viruses without inducing antibody-dependent enhancement (ADE). The vaccine demonstrated strong humoral and cellular immunity in mice and provided effective protection against lethal dengue virus challenges. Additionally, the use of cyclic-di-guanosine monophosphate as an adjuvant enhanced the immune response, indicating a promising strategy for dengue prevention.
- Author
- tienwebber
- Language
- EN