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Effects of antineoplastic agents on the peripheral nerves under a surgical tissue expansion procedure: An experimental study by M. Faruk Oktay; Ibrahim Askar; Ayse Yildirim; Ali Gurlek; Murat Akkus; Ismail Topcu; Faruk Meric is a Medicine article available to read on EtoBox.

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Background. Elongation of peripheral nerve by the use of a tissue expander is helpful to repair nerve defects. This study was designed to investigate the effects of some antineoplastic agents on the peripheral nerves under a surgical tissue expansion procedure. Materials and Methods. Twenty-five Wistar rats were used in this study. Following the exposition of the sciatic nerve and placement of two 10/0-nylon sutures in the epineurium 20 mm apart, a tissue expander was then placed under it. Inflation of the expander was immediately accomplished by the separate percutaneous injections of 6, 6, and 8 ml for every 3 min under general anesthesia. The expander was fully deflated at the end of each 3 min The distance between two sutures was measured 1 h later to measure the rate of elongation. Rats were randomly divided into five groups (according to the administered drugs), each consisting of five rats (10 sciatic nerves). Normal saline (1 ml) in the control group (group I), cyclophosphamide (15 mg/kg) in the group II, cisplatinum (3 lg/kg) in the group III, mitomycin-C (0.5 mg/kg) in the group IV and 5-fluorouracil (10 mg/kg) in the group V were injected intravenously. Intravenous injec

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Author

M. Faruk Oktay; Ibrahim Askar; Ayse Yildirim; Ali Gurlek; Murat Akkus; Ismail Topcu; Faruk Meric

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0738-1085)

Published

2006

Language

EN

Field

Medicine (Health Sciences)