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Randomized Clinical Trial of Micronized Flavonoids in the Early Control of Bleeding from Acute Internal Haemorrhoids by Dr M. C. Misra; R. Parshad is a Medicine article available to read on EtoBox.
What is Randomized Clinical Trial of Micronized Flavonoids in the Early Control of Bleeding from Acute Internal Haemorrhoids about?
## Abstract ## Background Patients with acute bleeding from internal haemorrhoids often have to be referred by the general practitioner to the surgeon for definitive treatment with invasive outpatient procedures. At the initial consultation, patients frequently seek postponement of immediate surgery to a more convenient time. Effective and rapid non-invasive control of acute bleeding could be of practical use in scheduling surgery to a time convenient to both patient and surgeon. ## Methods In a 90-day randomized, double-blind study treatment with a micronized purified flavonoid fraction (MPFF) was compared with placebo, in 100 outpatients who presented for treatment of acute internal haemorrhoids of less than 3 days' duration. The primary endpoint was cessation of bleeding on the third day of treatment. ## Results Of 50 patients randomized to each group, acute bleeding ceased by the third day in 40 (80 per cent) who received MPFF compared with 19 (38 per cent) who had placebo (P < 0·01). Mean(s.d.) duration of acute bleeding from onset to cessation of 4·9(1·6) days was 2·1 (95 per cent confidence interval 1·2–2·9) days less than that in patients receiving placebo (P < 0·01). Conti
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- Author
- Dr M. C. Misra; R. Parshad
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Oxford University Press (OUP) (ISSN 0007-1323)
- Published
- 2000
- Language
- EN
- Field
- Medicine (Health Sciences)