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Predictive value of thymidylate synthase expression in advanced colorectal cancer patients receiving fluoropyrimidine-based chemotherapy: Evidence from 24 studies by Li-Xin Qiu; Qi-Yun Tang; Jian-Ling Bai; Xiao-Ping Qian; Ru-Tian Li; Bao-Rui Liu; Ming-Hua Zheng is a Medicine article available to read on EtoBox.
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## Abstract The published data about thymidylate synthase (TS) expression and its predictive value in advanced colorectal cancer (CRC) patients receiving fluoropyrimidine‐based chemotherapy seemed inconclusive. To derive a more precise estimation of the relationship, a metaanalysis was performed. Studies have been identified by searching PubMed and Embase. Inclusion criteria were advanced CRC patients, received fluoropyrimidine‐based chemotherapy and evaluation of TS expression and overall response rate (ORR). The relative ratio (RR) for ORR in patients with low‐TS expression over those with high‐TS expression with 95% confidence interval (CI) was calculated for each study as an estimation of the predictive effect of TS. A total of 24 studies including 1,112 patients were involved in this metaanalysis. The overall RR was 2.20 (95% CI, 1.82–2.66; __p__ = 0.000). For studies evaluating TS expression in metastatic lesions, the pooled RR was 3.23 (95% CI, 2.27–4.59; __p__ = 0.000); for studies testing TS expression in primary lesions, a pooled RR of 1.89 (95% CI, 1.45–2.48; __p__ = 0.000) was estimated. Focusing the analysis on immunohistochemistry (IHC)‐based or RTPCR‐based assessment
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- Author
- Li-Xin Qiu; Qi-Yun Tang; Jian-Ling Bai; Xiao-Ping Qian; Ru-Tian Li; Bao-Rui Liu; Ming-Hua Zheng
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2008
- Language
- EN
- Field
- Medicine (Health Sciences)