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Can I read Liposomal remdesivir inhalation solution for targeted lung delivery as a novel therapeutic approach for COVID-19 on EtoBox?
Liposomal remdesivir inhalation solution for targeted lung delivery as a novel therapeutic approach for COVID-19 by Jingjing Li; Kai Zhang; Di Wu; Lianjie Ren; Xinyu Chu; Chao Qin; Xiaopeng Han; Taijun Hang; Yungen Xu; Lei Yang; Lifang Yin is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.
What is Liposomal remdesivir inhalation solution for targeted lung delivery as a novel therapeutic approach for COVID-19 about?
Strong infectivity enables coronavirus disease 2019 (COVID-19) to rage throughout the world. Moreover, the lack of drugs with definite therapeutic effects further aggravates the spread of the pandemic. Remdesivir is one of the most promising anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) drugs. However, the limited clinical effects make its therapeutic effect controversial, which may result from the poor accumulation and activation of remdesivir in the lung. Therefore, we developed lyophilized remdesivir liposomes (Rdv-lips) which can be reconstituted as liposomal aerosol for pulmonary delivery to improve the __in vivo__ behavior of existing remdesivir cyclodextrin conclusion compound (Rdv-cyc) injections. Liposome encapsulation endowed remdesivir with much higher solubility and better biocompatibility. The __in vitro__ liposomal aerosol characterization demonstrated that Rdv-lips possessed a mass median aerodynamic diameter of 4.118 μm and fine particle fraction (<5 μm) higher than 50%, indicating good pulmonary delivery properties. Compared to the Rdv-cyc intravenous injection group, the Rdv-lips inhalation group displayed a nearly 100-fold increase in the remd
Who reads Liposomal remdesivir inhalation solution for targeted lung delivery as a novel therapeutic approach for COVID-19?
It is typically read by researchers, students, and practitioners in Pharmacology, Toxicology and Pharmaceutics.
- Author
- Jingjing Li; Kai Zhang; Di Wu; Lianjie Ren; Xinyu Chu; Chao Qin; Xiaopeng Han; Taijun Hang; Yungen Xu; Lei Yang; Lifang Yin
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Pharmacology, Toxicology and Pharmaceutics (Life Sciences)