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Can I read Network pharmacology-based identification of protective mechanism of Panax Notoginseng Saponins on aspirin induced gastrointestinal injury on EtoBox?
Network pharmacology-based identification of protective mechanism of Panax Notoginseng Saponins on aspirin induced gastrointestinal injury by Zhu, Baochen; Zhang, Wantong; Lu, Yang; Hu, Shaonan; Gao, Rui; Sun, Zongxi; Chen, Xiaonan; Ma, Junming; Guo, Shuang; Du, Shouying; Li, Pengyue is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Network pharmacology-based identification of protective mechanism of Panax Notoginseng Saponins on aspirin induced gastrointestinal injury about?
## Background & aims: Aspirin is the first line therapy for cardiovascular and cerebrovascular diseases and is widely used. however aspirin-induced gastrointestinal injury is one of its most common side effect which limits long-term use. panax notoginseng saponins(pns) which is also used to prevent thrombus may alleviate this side effect according to previous clinical evidences. owing to the complexity of drug combination, the protective mechanism of pns on aspirin-induced gastrointestinal injury remains unclear. therefore, a network pharmacology-based strategy was proposed in this study to address this problem. ## Methods: A network pharmacology approach comprising multiple components, candidate targets of each component, known therapeutic targets, network analysis has been used in this study. also, we establish aspirin-induced gastrointestinal injury model by the oral administration of aspirin (0.5 g/kg body weight) to verify the predicted targets from network pharmacology. all rats was randomly allocated to control groups (n = 6),aspirin groups (n = 6)and aspirin + pns groups (n = 6) and conducted h&e staining and elisa for vegfa. ## Results: The comprehensive systematic approac
Who reads Network pharmacology-based identification of protective mechanism of Panax Notoginseng Saponins on aspirin induced gastrointestinal injury?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Zhu, Baochen; Zhang, Wantong; Lu, Yang; Hu, Shaonan; Gao, Rui; Sun, Zongxi; Chen, Xiaonan; Ma, Junming; Guo, Shuang; Du, Shouying; Li, Pengyue
- Publisher
- Elsevier Science; Elsevier ; Elsevier Masson; Elsevier BV (ISSN 0753-3322)
- Published
- 2018
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)