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Insights Into Extramedullary Tumour Cell Growth Revealed by Expression Profiling of Human Plasmacytomas and Multiple Myeloma by Cyrus V. Hedvat; Raymond L. Comenzo; Julie Teruya-Feldstein; Adam B. Olshen; Scott A. Ely; Keren Osman; Yana Zhang; Nagesh Kalakonda; Stephen D. Nimer is a Medicine article available to read on EtoBox.
What is Insights Into Extramedullary Tumour Cell Growth Revealed by Expression Profiling of Human Plasmacytomas and Multiple Myeloma about?
**Summary.** Malignant plasma cells generally grow within the bone marrow microenvironment; however, they can also grow at extramedullary sites. To identify the tumour‐specific alterations required for extramedullary growth, we analysed the expression profiles of a series of plasma cell neoplasms including primary multiple myeloma (MM), plasma cell leukaemia (PCL) and extramedullary plasmacytoma (EPC). Hierarchical clustering analysis segregated the EPCs from the remaining samples, and revealed an expression pattern associated with angiogenesis in the EPCs, involving higher expression of the genes TIE2, __NOTCH3__, CD31 and endoglin. Direct comparison of EPC samples with the MM samples identified 156 genes significantly upregulated and 85 genes significantly downregulated (__P__ < 0·005, __t__‐test) in the EPCs, including several genes involved in angiogenesis and adhesion that were upregulated (including angiopoietin 1, __SPARC,__ Notch3 and fibronectin 1). Immunohistochemical staining demonstrated CD31 and endoglin protein expression in the EPC tumour cells, which are both angiogenesis related and could confer malignant plasma cells with the ability to grow outside the normal bon
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- Author
- Cyrus V. Hedvat; Raymond L. Comenzo; Julie Teruya-Feldstein; Adam B. Olshen; Scott A. Ely; Keren Osman; Yana Zhang; Nagesh Kalakonda; Stephen D. Nimer
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)