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Facile Construction of Shape-regulated β-Cyclodextrin-based Supramolecular Self-assemblies for Drug Delivery by Yang Bai; Na An; Di Chen; Ying-zhe Liu; Cai-ping Liu; Hao Yao; Chao Wang; Xin Song; Wei Tian is a Materials Science article available to read on EtoBox.

What is Facile Construction of Shape-regulated β-Cyclodextrin-based Supramolecular Self-assemblies for Drug Delivery about?

Although supramolecular prodrug self-assemblies have been proven as efficient nanocarriers for cancer therapy, tedious synthesis procedures have made their practical applications more difficult. In this paper, β-cyclodextrin-based supramolecular self-assemblies (SSAs) were directly constructed by utilizing β-cyclodextrin trimer (β-CD) as the host unit and unmodified curcumin as the guest unit. Due to the adjustment of host-guest inclusion and hydrophilic-hydrophobic interactions occurring in the SSAs, their morphology could be readily tuned by changing the ratio of the two components. Different self-assembly morphologies, such as spherical complex micelles, spindle-like complex micelles and multi-compartment vesicles, were obtained. Furthermore, basic cell experiments were performed to study the corresponding effects of the SSA shape on their biological properties. Compared to the other micelles, the spindle-like complex micelles exhibited enhanced cellular toxicity, uptake behaviors and apoptosis rates, and the spherical complex micelles exhibited poor performance. The performance of the multi-compartment vesicles was similar to that of the spindle-like complex micelles. The facil

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Author

Yang Bai; Na An; Di Chen; Ying-zhe Liu; Cai-ping Liu; Hao Yao; Chao Wang; Xin Song; Wei Tian

Published

2019

Language

EN

Field

Materials Science (Physical Sciences)