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Diabetes per se and metabolic state influence gene expression in tissue‐dependent manner of BB/OK rats by Nora Klöting; Niels Follak; Ingrid Klöting is a Medicine article available to read on EtoBox.

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## Abstract ## Background Several epidemiologic studies have clearly established that long‐term near normoglycaemia strongly protects against onset and progression of late complication of diabetes. Therefore, insulin treatment plays a crucial role in determining the quality of life of affected individuals. Here we studied the effects of exogenous insulin on gene expression levels in well‐ and poorly compensated diabetic subjects in comparison to non‐diabetic BB/OK rats to find out whether diabetes per se and the quality of insulin treatment have an effect on gene expression and whether it is tissue specific. ## Methods Six non‐diabetic and 12 diabetic BB/OK rats were studied. Diabetic subjects were either treated with insulin implants (well compensated) or treated with 1U insulin daily (poorly compensated) to guarantee survival. Four weeks after onset of diabetes, the animals were killed and expression of __Yy1, Pparγ, Nfκb, Pref‐1, Tgfb1, Il‐10__, and __Lepr__ was measured in thymus, spleen, liver, heart, and bone. ## Results In general, between diabetic and non‐diabetic subjects, significant expression changes were detected in spleen for __Il‐10__, in heart for __Il‐10__ and __Pp

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Author

Nora Klöting; Niels Follak; Ingrid Klöting

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1520-7552)

Published

2004

Language

EN

Field

Medicine (Health Sciences)