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Differential roles of the Wip1–p38–p53 DNA damage response pathway in early/advanced-stage ovarian clear cell carcinomas by Chenyang Xu; Takeo Minaguchi; Nan Qi; Kaoru Fujieda; Asami Suto; Hiroya Itagaki; Ayumi Shikama; Nobutaka Tasaka; Azusa Akiyama; Sari Nakao; Hiroyuki Ochi; Toyomi Satoh is a Medicine article available to read on EtoBox.

What is Differential roles of the Wip1–p38–p53 DNA damage response pathway in early/advanced-stage ovarian clear cell carcinomas about?

## Background Ovarian clear cell carcinoma (OCCC) is one of the most lethal types of ovarian cancer. Early-stage OCCC can be cured by surgery; however, advanced-stage disease shows poor prognosis due to chemoresistance unlike the more common high-grade serous carcinoma. ## Methods We explored the differential roles of the Wip1–p38–p53 DNA damage response pathway in respective early- or advanced-stage OCCC by immunohistochemistry of Wip1, phospho-p38, p53, and phospho-p53 from consecutive 143 patients. ## Results High Wip1 expression correlated with positive p53 (__p__=0.011), which in turn correlated with low nuclear phospho-p38 expression (__p__=0.0094). In the early stages, positive p53 showed trends toward worse overall survival (OS) (__p__=0.062), whereas in the advanced stages, high Wip1 correlated with worse OS (__p__=0.0012). The univariate and multivariate analyses of prognostic factors indicated that high Wip1 was significant and independent for worse OS (__p__=0.011) in the advanced stages, but not in the early stages. Additionally, high Wip1 showed trends toward shorter treatment-free interval (TFI) in the advanced stages, but not in the early stages (__p__=0.083 vs. 0.9

Who reads Differential roles of the Wip1–p38–p53 DNA damage response pathway in early/advanced-stage ovarian clear cell carcinomas?

Author

Chenyang Xu; Takeo Minaguchi; Nan Qi; Kaoru Fujieda; Asami Suto; Hiroya Itagaki; Ayumi Shikama; Nobutaka Tasaka; Azusa Akiyama; Sari Nakao; Hiroyuki Ochi; Toyomi Satoh

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Medicine (Health Sciences)