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Organ-specific Metabolic Pathways Distinguish Prediabetes, Type 2 Diabetes, and Normal Tissues by Klev Diamanti; Marco Cavalli; Maria J. Pereira; Gang Pan; Casimiro Castillejo-López; Chanchal Kumar; Filip Mundt; Jan Komorowski; Atul S. Deshmukh; Matthias Mann; Olle Korsgren; Jan W. Eriksson; Claes Wadelius is a Medicine article available to read on EtoBox.

What is Organ-specific Metabolic Pathways Distinguish Prediabetes, Type 2 Diabetes, and Normal Tissues about?

Environmental and genetic factors cause defects in pancreatic islets driving type 2 diabetes (T2D) together with the progression of multi-tissue insulin resistance. Mass spectrometry proteomics on samples from five key metabolic tissues of a cross-sectional cohort of 43 multi-organ donors provides deep coverage of their proteomes. Enrichment analysis of Gene Ontology terms provides a tissue-specific map of altered biological processes across healthy, prediabetes (PD), and T2D subjects. We find widespread alterations in several relevant biological pathways, including increase in hemostasis in pancreatic islets of PD, increase in the complement cascade in liver and pancreatic islets of PD, and elevation in cholesterol biosynthesis in liver of T2D. Our findings point to inflammatory, immune, and vascular alterations in pancreatic islets in PD that are hypotheses to be tested for potential contributions to hormonal perturbations such as impaired insulin and increased glucagon production. This multi-tissue proteomic map suggests tissue-specific metabolic dysregulations in T2D.

Who reads Organ-specific Metabolic Pathways Distinguish Prediabetes, Type 2 Diabetes, and Normal Tissues?

Author

Klev Diamanti; Marco Cavalli; Maria J. Pereira; Gang Pan; Casimiro Castillejo-López; Chanchal Kumar; Filip Mundt; Jan Komorowski; Atul S. Deshmukh; Matthias Mann; Olle Korsgren; Jan W. Eriksson; Claes Wadelius

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)