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Anti-aging and Antioxidant of Four Traditional Malaysian Plants Using Simplex Centroid Mixture Design Approach by Ranneh, Yazan (author);Abu Bakar, Mohd Fadzelly (author);Ismail, Nur Amalina (author);Kormin, Faridah (author);Mohamed, Maryati (author);Md Akim, Abdah (author);Isha, Azizul (author) is a Agricultural and Biological Sciences article available to read on EtoBox.

What is Anti-aging and Antioxidant of Four Traditional Malaysian Plants Using Simplex Centroid Mixture Design Approach about?

Aging is a naturally biological process with adverse effects. The continuous accumulation of reactive oxygen species (ROS) trigger cellular and tissue damage by activating several aging enzymes. The antioxidant properties of traditional medicinal plants used by Jakun aborigine’s community are a promising approach to alleviate aging process and prevent Alzheimer. The aim of the current investigation was to optimize a novel anti-aging formulation from traditional plants (__Cnestis palala__ stem, __Urceola micrantha__ stem, __Marantodes pumilum__ stem and __Microporus xanthopus__ fruiting bodies) using simplex centroid mixture design (SCMD). After selecting the optimal formulations based on desirability function of antioxidant activity (DPPḢ, ABTS**^ ̇^**^+^ and FRAP), they were further examined against the activity of aging-related-enzymes (collagenase, tyrosinase, acetyl- and butyrylcholinesterase). The single extracts of __C__. __palala, U. micrantha__ and the binary mixture of __C. palala__ and __U. micrantha__ were the optimal formulations with high antioxidant activities. Single extract of __U. micrantha__ showed the highest inhibition towards matrix metalloproteinase-1 (49.44 ±

Who reads Anti-aging and Antioxidant of Four Traditional Malaysian Plants Using Simplex Centroid Mixture Design Approach?

It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.

Author
Ranneh, Yazan (author);Abu Bakar, Mohd Fadzelly (author);Ismail, Nur Amalina (author);Kormin, Faridah (author);Mohamed, Maryati (author);Md Akim, Abdah (author);Isha, Azizul (author)
Publisher
Elsevier BV
Published
2021
Language
EN
Field
Agricultural and Biological Sciences (Life Sciences)

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