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A Risk Assessment Tool for Predicting Fragility Fractures in People with HIV: Derivation and Internal Validation of the FRESIA Model by Pilar Vizcarra; Ana Moreno; María J. Vivancos; Alfonso Muriel García; Margarita Ramirez Schacke; Juan González‐Garcia; Adrián Curran; Rosario Palacios; Antonio Jesús Sánchez Guirao; Sergio Reus Bañuls; Santiago Moreno Guillén; José L. Casado; the Spanish HIV Research Network (CoRIS) is a Medicine article available to read on EtoBox.

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## Abstract People with HIV have a higher risk of fracture than the general population. Because of the low performance of the existing prediction tools, there is controversy surrounding fracture risk estimation in this population. The aim of the study was to develop a model for predicting the long‐term risk of fragility fractures in people with HIV. We included 11,899 individuals aged ≥30 years from the Spanish HIV/AIDS research network cohort. We identified incident fragility fractures from medical records, defined as nontraumatic or those occurring after a casual fall, at major osteoporotic sites (hip, clinical spine, forearm, proximal humerus). Our model accounted for the competing risk of death and included 12 candidate predictors to estimate the time to first fragility fracture. We assessed the discrimination and calibration of the model and compared it with the FRAX tool. The incidence rate of fragility fractures was 4.34 (95% CI 3.61 to 5.22) per 1000 person‐years. The final prediction model included age, chronic kidney disease, and chronic obstructive pulmonary disease as significant predictors. The model accurately predicted the 5‐ and 10‐year risk of fragility fractures,

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Author

Pilar Vizcarra; Ana Moreno; María J. Vivancos; Alfonso Muriel García; Margarita Ramirez Schacke; Juan González‐Garcia; Adrián Curran; Rosario Palacios; Antonio Jesús Sánchez Guirao; Sergio Reus Bañuls; Santiago Moreno Guillén; José L. Casado; the Spanish HIV Research Network (CoRIS)

Publisher

Wiley

Published

2023

Language

EN

Field

Medicine (Health Sciences)