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Can I read Tandem optimization of target activity and elimination of mutagenic potential in a potent series of N-aryl bicyclic hydantoin-based selective androgen receptor modulators on EtoBox?
Tandem optimization of target activity and elimination of mutagenic potential in a potent series of N-aryl bicyclic hydantoin-based selective androgen receptor modulators by Lawrence G. Hamann; Mark C. Manfredi; Chongqing Sun; Stanley R. Krystek Jr.; Yanting Huang; Yingzhi Bi; David J. Augeri; Tammy Wang; Yan Zou; David. A. Betebenner; Aberra Fura; Ramakrishna Seethala; Rajasree Golla; Joyce E. Kuhns; John A. Lupisella; Celia J. Darienzo; Laura L. Custer; Jennifer L. Price; James M. Johnson; Scott A. Biller; Robert Zahler; Jacek Ostrowski is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Tandem optimization of target activity and elimination of mutagenic potential in a potent series of N-aryl bicyclic hydantoin-based selective androgen receptor modulators about?
Pharmacokinetic studies in cynomolgus monkeys with a novel prototype selective androgen receptor modulator revealed trace amounts of an aniline fragment released through hydrolytic metabolism. This aniline fragment was determined to be mutagenic in an Ames assay. Subsequent concurrent optimization for target activity and avoidance of mutagenicity led to the identification of a pharmacologically superior clinical candidate without mutagenic potential.
Who reads Tandem optimization of target activity and elimination of mutagenic potential in a potent series of N-aryl bicyclic hydantoin-based selective androgen receptor modulators?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Lawrence G. Hamann; Mark C. Manfredi; Chongqing Sun; Stanley R. Krystek Jr.; Yanting Huang; Yingzhi Bi; David J. Augeri; Tammy Wang; Yan Zou; David. A. Betebenner; Aberra Fura; Ramakrishna Seethala; Rajasree Golla; Joyce E. Kuhns; John A. Lupisella; Celia J. Darienzo; Laura L. Custer; Jennifer L. Price; James M. Johnson; Scott A. Biller; Robert Zahler; Jacek Ostrowski
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2007
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)