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Multicentric assessment of the efficacy and tolerability of dihydroartemisinin-piperaquine compared to artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in sub-Saharan Africa by William Yavo; Babacar Faye; Thomas Kuete; Vincent Djohan; Serge A Oga; Richard R Kassi; Mariama Diatta; Moor V Ama; Roger Tine; Jean-Louis Ndiaye; Jean-Bedel Evi; Albert Same-Ekobo; Oumar Faye; Moussa Koné is a Medicine article available to read on EtoBox.

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## Background The choice of appropriate artemisinin-based combination therapy depends on several factors (cost, efficacy, safety, reinfection rate and simplicity of administration). To assess whether the combination dihydroartemisinin-piperaquine (DP) could be an alternative to artemether-lumefantrine (AL), the efficacy and the tolerability of the two products for the treatment of uncomplicated falciparum malaria in sub-Saharan Africa have been compared. ## Methods A multicentric open randomized controlled clinical trial of three-day treatment of DP against AL for the treatment of two parallel groups of patients aged two years and above and suffering from uncomplicated falciparum malaria was carried out in Cameroon, Côte d'Ivoire and Senegal. Within each group, patients were randomly assigned supervised treatment. DP was given once a day for three days and AL twice a day for three days. Follow-up visits were performed on day 1 to 4 and on day 7, 14, 21, 28 to evaluate clinical and parasitological results. The primary endpoint was the recovery rate by day 28. ## Results Of 384 patients enrolled, 197 were assigned DP and 187 AL. The recovery rates adjusted by genotyping, 99.5% in the

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Author

William Yavo; Babacar Faye; Thomas Kuete; Vincent Djohan; Serge A Oga; Richard R Kassi; Mariama Diatta; Moor V Ama; Roger Tine; Jean-Louis Ndiaye; Jean-Bedel Evi; Albert Same-Ekobo; Oumar Faye; Moussa Koné

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2002-; Springer Science and Business Media LLC; Research Square (ISSN 1475-2875)

Published

2011

Language

EN

Field

Medicine (Health Sciences)